Nanoparticle biocoating to create ATP-powered swimmers capable of repairing proteins on the fly

One of the most attractive futuristic challenges in nanomedicine is to create self-propelled nanorobots scan and repair living tissues at nano/microscale. Ideally, these devices should navigate using local, inexhaustible biomolecules as energy sources, while performing different functions, such delivering drugs or repairing tissues. In this study, we combine nanotechnology biotechnology design a biocompatible propulsion system based on molecular chaperone Hsp90, heat-shock protein (Hsp) that, presence adenosine 5′-triphosphate (ATP), undergoes nanoscale conformational changes trapping renaturing other proteins. We show how, subjected ATP availability medium, Hsp90-functionalized particles significantly enhance their diffusion motion, being able achieve ballistic keeping ability restore activity surrounding heat-inactivated This biomechanics-based mechanism represents promising strategy for nanodevices capable sophisticated tasks live biological contexts that include sensing environment, recognizing capturing, folding, restoring defective proteins fly. short term, Hsp90-driven could be applied improve industrial processes require enzymatic catalysis high temperatures. But medium long bioactive coating used nanomachines like mini-robots, complex body cavities tissues, deliver therapies and/or remove misfolded disorders Alzheimer's Parkinson's disease.